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ARTICLE
Year : 2010  |  Volume : 33  |  Issue : 4  |  Page : 195-198

Effect of caffeine on radiation induced micronuclei in human lymphocytes


1 Department of Biophysics, Government Institute of Science, Aurangabad, India
2 Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Correspondence Address:
K B Anjaria
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Trombay, Mumbai
India
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Source of Support: None, Conflict of Interest: None


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Present study reports the effect of caffeine on 60 Co gamma radiation induced micronuclei in human peripheral blood lymphocytes. Lymphocytes were pre-treated with 0.1-10μM caffeine for 1h at 37°C and exposed to 2 and 4 Gy of radiation before culturing for 72h. In another set of experiments, lymphocytes were exposed to 2 and 4 Gy of radiation and subsequently cultured in the presence of caffeine. Caffeine pre-treatment significantly reduced radiation induced micronuclei (MN) in a concentration dependent manner. In contrast, post-irradiation treatment with caffeine significantly potentiated radiation induced MN in a concentration dependent manner.


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