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ARTICLE
Year : 2010  |  Volume : 33  |  Issue : 4  |  Page : 199-201

Effect of tumour promoter iodoacetate on γ-radiation induced chromosomal aberrations in human lymphocytes


Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Correspondence Address:
K B Anjaria
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Trombay, Mumbai
India
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Source of Support: None, Conflict of Interest: None


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Iodoacetate (IA) is a known tumour promoter of moderate potency. Present study reports the effect of IA post-treatment on 60 Co gamma radiation induced chromosomal aberrations in human peripheral blood lymphocytes. Cells were exposed to 2 or 4 Gy of radiation and were cultured in the presence of 0.25-2.5 μg/ml IA. It was observed that IA reduced radiation induced dicentrics yield significantly at both the radiation doses.


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